Abstract

Nutrition-related noncommunicable diseases (NR-NCDs) such as cardiovascular disease and type 2 diabetes both negatively impact the quality of life of many individuals and generate a substantial burden on society, demonstrating a need for intervention. Phytochemicals are investigated as a potential approach for combating NR-NCDs, and those found in hops have gained increased attention in recent decades. Hops, the strobile of the plant Humulus lupulus, are grown primarily for the brewing industry as they confer taste and increased shelf-life. The bitter acids represent the main compounds of interest for improving beer quality. Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This review summarizes those beneficial effects of bitter acids and xanthohumol on NR-NCDs, including inflammatory and immune diseases, obesity and metabolic disorders, as well as cancer prevention.

摘要

与营养有关的非传染性疾病（NR-NCD），例如心血管疾病和2型糖尿病，都对许多人的生活质量产生负面影响，并给社会造成沉重负担，这表明需要进行干预。对植物化学物质进行了研究，认为它是与NR-NCD对抗的潜在方法，近几十年来，在啤酒花中发现的植物化学物质受到了越来越多的关注。啤酒花，植物的球果啤酒花，主要用于酿造业，因为它们赋予味道和增加的保质期。苦味酸代表了改善啤酒品质的主要目标化合物。另外，苦味酸以及烯丙基查尔酮黄腐酚具有广泛的健康有益特性。这篇综述总结了苦味酸和黄腐酚对NR-NCD的有益作用，包括炎性和免疫性疾病，肥胖症和代谢紊乱以及癌症预防。