Glycosaminoglycan (GAG) is a chain-like disaccharide that is linked to a polypeptide core to connect two collagen fibrils/fibers and provide the intermolecular force in a Collagen-GAG matrix which can be a valuable treatment of post-burn contractures and hypertrophic scars, which remain a challenge to reconstructive surgery. The face and neck contractures are the most difficult sites to treat. This article is meant to discuss our clinical experience in using collagen-glycosaminoglycan biodegradable matrix (Integra^® Integra Lifesciences Corporation, Plainsboro, NJ, USA) to reconstruct defects created by excision of contracted areas from the neck and lower face areas. Between 2009 and 2011, we had 11 patients that underwent Integra reconstructive procedures. The mean follow-up period was 18 months. For all the patients, the intake of the Integra dermal regeneration template was 100%, even if one patient developed a minor infection treated with appropriate antibiotics. The patients are very satisfied with the result. A minor problem was a small difference in skin color, but this inconvenience was compensated by good skin elasticity.

中文翻译：

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胶原蛋白-糖胺聚糖生物可降解基质（Integra®）在颈部烧伤后肥厚性瘢痕和挛缩的治疗中的应用

糖胺聚糖（GAG）是一种链状二糖，与多肽核心相连，连接两个胶原纤维/纤维，并在胶原GAG基质中提供分子间作用力，可以有效治疗烧伤后挛缩和肥厚性瘢痕，这仍然是重建手术的挑战。面部和颈部挛缩是最难治疗的部位。本文旨在讨论使用胶原糖胺聚糖的生物可降解基质（的Integra我们的临床经验^®Integra Lifesciences Corporation，美国新泽西州普莱恩斯伯勒），用于修复从颈部和下面部切开收缩区域而产生的缺陷。在2009年至2011年之间，我们有11例患者接受了Integra重建手术。平均随访期为18个月。对于所有患者，即使一名患者发生了轻度感染并用适当的抗生素治疗，Integra皮肤再生模板的摄入量也为100％。患者对结果非常满意。一个较小的问题是肤色差异很小，但是这种不便之处可以通过良好的皮肤弹性得到补偿。