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Redundant Anaerobic Antimicrobial Prescriptions in German Acute Care Hospitals: Data from a National Point Prevalence Survey.
Antibiotics ( IF 4.8 ) Pub Date : 2020-05-28 , DOI: 10.3390/antibiotics9060288 Seven Johannes Sam Aghdassi 1, 2 , Petra Gastmeier 1, 2 , Michael Behnke 1, 2 , Sonja Hansen 1, 2 , Tobias Siegfried Kramer 1, 2
Antibiotics ( IF 4.8 ) Pub Date : 2020-05-28 , DOI: 10.3390/antibiotics9060288 Seven Johannes Sam Aghdassi 1, 2 , Petra Gastmeier 1, 2 , Michael Behnke 1, 2 , Sonja Hansen 1, 2 , Tobias Siegfried Kramer 1, 2
Affiliation
Despite limited indications, redundant anaerobic antimicrobial prescriptions (RAAPs) are frequent. The objective of this study was to assess the prevalence and characteristics of RAAPs in German acute care hospitals. In a retrospective data analysis, antimicrobial prescriptions from a point prevalence survey on antimicrobial use in German acute care hospitals in 2016 were analyzed and RAAPs were identified. RAAPs were defined as a patient simultaneously receiving any of the following combinations: Penicillin/beta-lactamase inhibitor (PenBLI) plus clindamycin; PenBLI plus metronidazole; PenBLI plus moxifloxacin; PenBLI plus carbapenem; carbapenem plus clindamycin; carbapenem plus metronidazole; carbapenem plus moxifloxacin; clindamycin plus metronidazole; clindamycin plus moxifloxacin; and metronidazole plus moxifloxacin. Data from 64,412 patients in 218 hospitals were included. Overall, 4486 patients (7%) received two or more antimicrobials. In total, 441 RAAP combinations were identified. PenBLI plus metronidazole was the most common anaerobic combination (N = 166, 38%). The majority of RAAPs were for the treatment of community-acquired (N = 258, 59%) infections. Lower respiratory tract infections (N = 77; 20%) and skin/soft tissue infections (N = 76; 20%) were the most frequently recorded types of infections. RAAPs are common in German hospitals. Reducing redundant antimicrobial coverage should be a key component of future antimicrobial stewardship activities.
中文翻译:
德国急性护理医院的冗余厌氧抗菌药物处方:国家点流行率调查数据。
尽管适应症有限,但经常使用多余的厌氧抗菌处方(RAAP)。这项研究的目的是评估德国急诊医院中RAAP的患病率和特征。 在一项回顾性数据分析中,分析了2016年德国急诊医院抗菌药物使用点流行调查中的抗菌药物处方,并确定了RAAP。RAAP被定义为同时接受以下任何组合的患者:青霉素/β-内酰胺酶抑制剂(PenBLI)加克林霉素;PenBLI加甲硝唑;PenBLI加莫西沙星;PenBLI加碳青霉烯; 碳青霉烯加克林霉素; 碳青霉烯加甲硝唑; 碳青霉烯加莫西沙星; 克林霉素加甲硝唑;克林霉素加莫西沙星;和甲硝唑加莫西沙星。 包括来自218家医院的64,412名患者的数据。总体而言,有4486例患者(占7%)接受了两种或更多种抗菌药物。总共确定了441种RAAP组合。PenBLI加甲硝唑是最常见的厌氧组合(N = 166,38 %)。大部分RAAP用于治疗社区获得性感染(N = 258,59 %)。下呼吸道感染(N = 77; 20%)和皮肤/软组织感染(N = 76; 20%)是最常见的感染类型。 RAAP在德国医院很常见。减少多余的抗菌药物覆盖应该是未来抗菌管理活动的关键组成部分。
更新日期:2020-05-28
中文翻译:
德国急性护理医院的冗余厌氧抗菌药物处方:国家点流行率调查数据。
尽管适应症有限,但经常使用多余的厌氧抗菌处方(RAAP)。这项研究的目的是评估德国急诊医院中RAAP的患病率和特征。 在一项回顾性数据分析中,分析了2016年德国急诊医院抗菌药物使用点流行调查中的抗菌药物处方,并确定了RAAP。RAAP被定义为同时接受以下任何组合的患者:青霉素/β-内酰胺酶抑制剂(PenBLI)加克林霉素;PenBLI加甲硝唑;PenBLI加莫西沙星;PenBLI加碳青霉烯; 碳青霉烯加克林霉素; 碳青霉烯加甲硝唑; 碳青霉烯加莫西沙星; 克林霉素加甲硝唑;克林霉素加莫西沙星;和甲硝唑加莫西沙星。 包括来自218家医院的64,412名患者的数据。总体而言,有4486例患者(占7%)接受了两种或更多种抗菌药物。总共确定了441种RAAP组合。PenBLI加甲硝唑是最常见的厌氧组合(N = 166,38 %)。大部分RAAP用于治疗社区获得性感染(N = 258,59 %)。下呼吸道感染(N = 77; 20%)和皮肤/软组织感染(N = 76; 20%)是最常见的感染类型。 RAAP在德国医院很常见。减少多余的抗菌药物覆盖应该是未来抗菌管理活动的关键组成部分。