Kinetic study of organic reactions, especially multistep catalytic reactions, is crucial to in-depth understanding of reaction mechanisms. Here we report our kinetic study on the chiral disulfonimide-catalyzed cyanosilylation of an aldehyde, which revealed that two molecules of TMSCN are involved in the rate-determining C–C bond-forming step. In addition, the apparent activation energy, enthalpy of activation, and entropy of activation were deduced through a study of the temperature dependence of the reaction rates. More importantly, a novel and efficient method that makes use of the progress rates was developed to treat kinetic data obtained by continuous monitoring of the progress of a reaction by in situ FTIR.

中文翻译：

---

用进展速率法研究二磺酰亚胺催化醛类氰基硅烷化反应的动力学

有机反应的动力学研究，尤其是多步催化反应，对于深入了解反应机理至关重要。在这里，我们报告了我们对醛的手性二磺酰亚胺催化的氰基硅烷化的动力学研究，该研究表明两个分子的 TMSCN 参与了 C-C 键形成的速率决定步骤。此外，通过研究反应速率的温度依赖性，推导出表观活化能、活化焓和活化熵。更重要的是，开发了一种利用进展率的新型有效方法来处理通过原位 FTIR 连续监测反应进展获得的动力学数据。