Oligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and chromatin remodeling events. ATP‐dependent chromatin remodeling enzymes, which utilize ATP as an energy source to control chromatin dynamics and regulate the accessibility of chromatin to transcriptional regulators, are critical for oligodendrocyte lineage development and regeneration. In this review, we focus on the latest insights into the spatial and temporal specificity of chromatin remodelers during oligodendrocyte development, myelinogenesis, and regeneration. We will also bring together various plausible mechanisms by which lineage specific transcriptional regulators coordinate with chromatin remodeling factors for programming genomic landscapes to specifically modulate these different processes during developmental myelination and remyelination upon injury.

中文翻译：

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少突胶质细胞中的染色质重塑剂。

少突胶质细胞，脊椎动物中枢神经系统中的髓鞘细胞，产生髓鞘，使动作电位的跳跃式传播成为可能。少突胶质细胞髓鞘形成过程需要从前体规范到分化的逐步进展，这是由一系列转录和染色质重塑事件协调的。依赖 ATP 的染色质重塑酶利用 ATP 作为能源来控制染色质动力学并调节染色质对转录调节因子的可及性，对于少突胶质细胞谱系的发育和再生至关重要。在这篇综述中，我们专注于对少突胶质细胞发育、髓鞘形成和再生过程中染色质重塑剂的空间和时间特异性的最新见解。