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Tissue regulatory T cells.
Immunology ( IF 6.4 ) Pub Date : 2020-05-28 , DOI: 10.1111/imm.13208
Prudence PokWai Lui 1 , Inchul Cho 1 , Niwa Ali 1, 2
Affiliation  

Foxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially. Only recently, the importance of Tregs residing within non‐lymphoid tissues, such as visceral adipose tissue, muscle, skin and intestine, has been recognized. Not only are Tregs critical for influencing the kinetics and strength of immune responses, but the regulation of non‐immune or parenchymal cells, also fall within the purview of tissue‐resident or infiltrating Tregs. This review focuses on providing a systematic and comprehensive comparison of the molecular maintenance, local adaptation and functional specializations of Treg populations operating within different tissues.

中文翻译:

组织调节性T细胞。

Foxp3 +  CD4 +调节性 T 细胞 (Treg) 是一种免疫细胞谱系,在多种情况下都具有免疫抑制功能,包括抗病原体和抗自身反应。在过去的几十年里,我们对循环或淋巴 Tregs 功能多样性的了解呈指数级增长。直到最近,人们才认识到存在于非淋巴组织(例如内脏脂肪组织、肌肉、皮肤和肠道)中的 Tregs 的重要性。Tregs 不仅对影响免疫反应的动力学和强度至关重要,而且对非免疫或实质细胞的调节也属于组织驻留或浸润性 Tregs 的范围。本综述的重点是对不同组织内 Treg 群体的分子维持、局部适应和功能特化进行系统、全面的比较。
更新日期:2020-05-28
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