Activity‐dependent changes have been reported in animal models and in human epileptic specimens and could potentially be used as tissue biomarkers to evaluate the propensity of a tissue to generate seizure activity. In this context, cAMP‐response element binding protein (CREB) activation was specifically reported in human epileptic foci and related mainly to interictal spike activity. To get further insights into CREB activation in human epilepsy, we analyzed pCREB expression on brain tissue samples from patients who underwent surgery for drug‐resistant focal epilepsy, correlating this expression with intracranial stereo–electroencephalography (SEEG) recording in a subgroup.

中文翻译：

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来自癫痫手术的人体组织中的 pCREB ​​表达

在动物模型和人类癫痫标本中已经报道了活动依赖性变化，并且有可能用作组织生物标志物来评估组织产生癫痫活动的倾向。在这种情况下，cAMP 反应元件结合蛋白 (CREB) 激活在人类癫痫病灶中有特别报道，主要与发作间期棘突活动有关。为了进一步了解人类癫痫中 CREB ​​的激活，我们分析了接受抗药性局灶性癫痫手术的患者脑组织样本上的 pCREB ​​表达，并将该表达与亚组中的颅内立体脑电图 (SEEG) 记录相关联。