A new 9,11‐secosteroid, (22R)‐22‐acetoxy‐3β,6α,11‐trihydroxy‐9,11‐seco‐5α‐cholest‐7‐en‐9‐one, along with twelve known analogues were isolated from the South China Sea gorgonian coral Iciligorgia sp. Their structures were determined by the spectroscopic analysis and comparison with reported data. In an in vitro test of osteoclastic differentiation, three compounds exhibited significant down‐regulating effect whereas two compounds showed significant up‐regulating effect at 0.5 and 1.0 μm. This is the first report of the chemical investigation of the gorgonian Iciligorgia sp. The acetoxy substitution at C‐22 seems to play an important role in the regulating activity.

中文翻译：

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来自南海柳珊瑚 Iciligorgia sp. 的破骨细胞生成调节类固醇。

一种新的 9,11-secosteroid, (22R)-22-acetoxy-3β,6α,11-trihydroxy-9,11-seco-5α-cholest-7-en-9-one，连同十二个已知的类似物从南海柳珊瑚 Iciligorgia sp. 它们的结构是通过光谱分析和与报告数据的比较来确定的。在破骨细胞分化的体外试验中，三种化合物表现出显着的下调作用，而两种化合物在 0.5 和 1.0 μm 处表现出显着的上调作用。这是柳珊瑚 Iciligorgia sp 化学调查的第一份报告。C-22 处的乙酰氧基取代似乎在调节活性中起重要作用。