Background

A relationship has been proposed between increases in oral Candida concentrations and host immunity. Therefore, the present study was conducted to investigate the relationship between oral Candida mannan concentrations and symptoms/signs of ill health and the immune status and also to examine whether health/the immune status may be evaluated based on oral Candida mannan concentrations.

Patients and Methods

The health conditions of 25 healthy individuals and 10 cancer patients receiving cytotoxic chemotherapy were assessed using a questionnaire and oral rinse solutions collected on consecutive days. Candida mannan concentrations in oral rinse solutions were measured using a commercial sandwich ELISA kit.

Results

The use of dentures was identified as a significant independent factor increasing Candida mannan concentrations. In a stratified analysis based on the use of dentures, significantly increased Candida mannan concentrations were detected in healthy volunteers with chills and in cancer patients with slight/moderate fever (37.5–38.4 °C) (multivariate analysis, p < 0.01) who were non-denture users. These symptoms/signs may be associated with (pre-)infection, during which the immune system is activated and needs to function well.

Conclusions

The present results suggest that oral Candida mannan concentrations are a predictive marker for health/the immune status.

中文翻译：

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口腔念珠菌甘露聚糖浓度与不健康的症状/体征和免疫状态相关。

背景

已提出口腔念珠菌浓度增加与宿主免疫力之间存在关系。因此，本研究旨在调查口服念珠菌甘露聚糖浓度与健康不良症状/体征和免疫状态之间的关系，并检查是否可以根据口服念珠菌甘露聚糖浓度评估健康/免疫状态。

患者和方法

使用问卷和连续几天收集的口腔冲洗液对 25 名健康个体和 10 名接受细胞毒性化疗的癌症患者的健康状况进行了评估。使用商业夹心 ELISA 试剂盒测量口腔冲洗液中念珠菌甘露聚糖的浓度。

结果

假牙的使用被确定为增加念珠菌甘露聚糖浓度的重要独立因素。在基于假牙使用的分层分析中，在发冷的健康志愿者和有轻度/中度发热（37.5-38.4°C）（多变量分析，p  < 0.01）的癌症患者中检测到念珠菌甘露聚糖浓度显着增加。- 假牙使用者。这些症状/体征可能与（预）感染有关，在此期间免疫系统被激活并需要正常运作。

结论

目前的结果表明口服念珠菌甘露聚糖浓度是健康/免疫状态的预测标志物。