Purpose of Review

This review summarizes the effects of microparticles and exosomes in the progression of atherosclerosis and the prospect for their diagnostic and therapeutic potentials.

Recent Findings

Microparticles and exosomes can induce endothelial dysfunction, vascular inflammation, coagulation, thrombosis, and calcification via their components of proteins and noncoding RNAs, which may promote the progression of atherosclerosis. The applications of microparticles and exosomes become the spotlight of clinical diagnosis and therapy.

Summary

Microparticles and exosomes are members of extracellular vesicles, which are generated in various cell types by different mechanisms of cell membrane budding and multivesicular body secretion, respectively. They are important physiologic pathways of cell-to-cell communication in vivo and act as messengers accelerating or alleviating the process of atherosclerosis. Microparticles and exosomes may become diagnostic biomarkers and therapeutic approaches of atherosclerosis.

中文翻译：

---

微粒（外泌体）和动脉粥样硬化。

审查目的

这篇综述总结了微粒和外来体在动脉粥样硬化进展中的作用以及它们的诊断和治疗潜力。

最近的发现

微粒和外泌体可通过其蛋白质和非编码RNA成分诱导内皮功能障碍，血管炎症，凝血，血栓形成和钙化，从而促进动脉粥样硬化的发展。微粒和外泌体的应用成为临床诊断和治疗的重点。

概要

微粒和外泌体是细胞外囊泡的成员，它们通过细胞膜出芽和多囊泡体分泌的不同机制分别在各种细胞类型中产生。它们是体内细胞间通讯的重要生理途径，并充当使或加速或减轻动脉粥样硬化进程的使者。微粒和外泌体可能成为动脉粥样硬化的诊断生物标志物和治疗方法。