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Programmed genome rearrangements in ciliates.
Cellular and Molecular Life Sciences ( IF 8 ) Pub Date : 2020-05-27 , DOI: 10.1007/s00018-020-03555-2
Iwona Rzeszutek 1 , Xyrus X Maurer-Alcalá 2 , Mariusz Nowacki 2
Affiliation  

Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as DNA amplification. In this review, we discuss the similarities and differences in the genome reorganization processes of the model ciliates Paramecium and Tetrahymena (class Oligohymenophorea), and the distantly related Euplotes, Stylonychia, and Oxytricha (class Spirotrichea).



中文翻译:

纤毛虫的程序化基因组重排。

纤毛虫是高度分化的单细胞真核生物,在不同的双态核中具有分离的体细胞和种系基因组。在性生活后,新的体细胞基因组/细胞核的发育过程中,该特征与极其费力的发育调控基因组重排紧密相关。从种系到体细胞基因组的转化涉及由非编码RNA介导的大量DNA消除,染色体片段化以及DNA扩增。在这次审查中,我们讨论了模型纤毛虫的基因重组过程中的异同草履虫四膜虫(类Oligohymenophorea),和远亲游仆棘尾,和尖毛虫 (螺旋藻类)。

更新日期:2020-05-27
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