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Radiofrequency Monitoring of Intracranial Hemorrhage in the Neurological Intensive Care Unit: A Pilot Trial of the SENSE Device
medRxiv - Neurology Pub Date : 2020-05-26 , DOI: 10.1101/2020.05.25.20109108
Joseph J. Korfhagen , George J. Shaw , Matthew L. Flaherty , Opeolu Adeoye , William A. Knight

Intracerebral hemorrhage (ICH) is a devastating form of stroke, with substantial mortality and morbidity. Hemorrhage expansion (HE) occurs in ∼40% of patients and portends worse neurologic outcome and mortality. Currently, ICH patients are admitted to the intensive care unit (ICU) and monitored for HE with neurologic exam and neuroimaging. By the time a change is detected, it may be too late to mitigate HE. There is a clinical need for a non-invasive bedside monitor of ICH. The SENSE consists of a 9-antenna array mounted around the head with driving electronics. A 913 MHz signal is transmitted by a given antenna, crosses the intracranial region, and received by the remaining 8 antennae. A complete measurement consists of one cycle with each antenna serving as the transmitting antenna. It was hypothesized that HE of ≥ 3 ml would be detected by the device. Ten ICH subjects admitted within 24 hours of stroke onset were enrolled. All patients received a diagnostic head CT (baseline), and a repeat head CT at 12 (+/- 6) hours. ICH volumes were determined by blinded neuroradiologist reading, and a significant HE from baseline was considered ≥ 3 ml. Subjects were scanned with the device every 10 minutes for up to 72 hours. Data from one subject was lost from operator error. Among the remaining nine, two experienced HE of ≥ 3ml (3 and 8.2 ml respectively). SENSE device readings were 100% concordant with the CT scan results.

中文翻译:

神经内科重症监护病房的颅内出血的射频监测:SENSE装置的试验性试验

脑出血(ICH)是中风的毁灭性形式,具有相当大的死亡率和发病率。约40%的患者发生出血扩大(HE),预示着神经系统的预后和死亡率下降。目前,ICH患者被送入重症监护病房(ICU),并通过神经系统检查和神经影像学检查以监测其HE。到检测到变化时,减轻HE可能为时已晚。临床上需要一种非侵入性的ICH床旁监护仪。SENSE由一个9天线阵列组成,该阵列安装在带有驱动电子装置的磁头周围。913 MHz信号由给定天线发送,穿过颅内区域,并由其余8个天线接收。一个完整的测量包括一个周期,每个天线用作发射天线。假设该设备可检测到HE≥3 ml。招募了中风发作后24小时内收治的10名ICH受试者。所有患者均接受了诊断性头颅CT(基线),并在12(+/- 6)小时进行了头颅CT复查。ICH的体积由神经放射科医生的盲法读数确定,并且从基线开始的明显HE≥3 ml。每隔10分钟用设备扫描对象长达72小时。由于操作员错误,丢失了一个受试者的数据。在其余的9个中,有2个的HE≥3ml(分别为3 ml和8.2 ml)。SENSE设备读数与CT扫描结果100%一致。ICH的体积由神经放射科医生的盲法读数确定,并且从基线开始的明显HE≥3 ml。每隔10分钟用设备扫描对象长达72小时。由于操作员错误,丢失了一个受试者的数据。在其余的9个中,有2个的HE≥3ml(分别为3 ml和8.2 ml)。SENSE设备读数与CT扫描结果100%一致。ICH的体积由神经放射科医生的盲法读数确定,并且从基线开始的明显HE≥3 ml。每隔10分钟用设备扫描对象长达72小时。由于操作员错误,丢失了一个受试者的数据。在其余的9个中,有2个的HE≥3ml(分别为3 ml和8.2 ml)。SENSE设备读数与CT扫描结果100%一致。
更新日期:2020-05-26
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