Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the anti-osteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway.

中文翻译：

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白藜芦醇通过抑制p53促进成骨，减轻骨质疏松。

尽管骨质疏松症是最常见的与年龄相关的慢性疾病之一，但目前尚无治疗的金标准。有证据表明，白藜芦醇是一种天然的多酚类化合物，可能有助于治疗骨质疏松症和其他疾病。然而，白藜芦醇的抗骨质疏松作用的分子机制仍是未知之数。在本研究中，对白藜芦醇靶向基因的KEGG途径富集分析确定了33个相关途径，其中12个也参与了骨质疏松症。特别是，MDM2 / p53信号通路被确定为共享通路中潜在的关键通路。体外实验表明，MDM2介导的p53降解诱导成骨细胞分化，而白藜芦醇可以部分逆转p53依赖性成骨细胞分化的抑制作用。这些发现表明白藜芦醇可以通过调节MDM2 / p53信号通路至少部分缓解骨质疏松症。