ABSTRACT

This study was designed to evaluate the effects of alprostadil on patients with refractory heart failure receiving statin treatment. One hundred patients with refractory heart failure were categorized into two groups, control (n = 50) and intervention (n = 50). The control group was treated with statins only, while the intervention group received a combination treatment with alprostadil and statins. Total effective rate, New York Heart Association (NYHA) functional classification, quality of life (QOL) score, ventricular remodeling indices, oxidative stress indices, inflammatory factor index, and the serum levels of B-type natriuretic peptide (BNP), blood lipid, blood glucose, and insulin were compared between the two groups. The total effective rate of the intervention group was significantly higher than that of the control group. Following treatment, the intervention group experienced more significant improvements in terms of NYHA functional class, QOL scores, ventricular remodeling indices, oxidative stress indices, and serum levels of inflammatory factor, BNP, blood lipid, blood glucose, and insulin compared with the control group. Administration of alprostadil to patients with refractory heart failure receiving statin treatment can increase the total effective rate; down-regulate serum levels of inflammatory factor, BNP, blood lipid, and blood glucose; and improve insulin resistance, illustrating its value in this clinical application.

摘要

本研究旨在评估前列地尔对接受他汀类药物治疗的难治性心力衰竭患者的影响。将100例难治性心力衰竭患者分为两组，对照组（n  = 50）和干预组（n = 50）。对照组仅接受他汀类药物治疗，而干预组接受前列地尔和他汀类药物联合治疗。总有效率，纽约心脏协会（NYHA）功能分类，生活质量（QOL）评分，心室重构指数，氧化应激指数，炎症因子指数以及B型利钠肽（BNP）的血清水平，血脂比较两组的血糖，血糖和胰岛素。干预组的总有效率明显高于对照组。治疗后，干预组在NYHA功能类别，QOL评分，心室重塑指数，氧化应激指数以及血清炎症因子，BNP，血脂，血糖，和胰岛素相比，对照组。对接受他汀类药物治疗的难治性心力衰竭患者使用前列地尔可以提高总有效率；下调血清炎症因子，BNP，血脂和血糖水平；并改善胰岛素抵抗，说明其在该临床应用中的价值。