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Persistent Asymptomatic Human Infections by Salmonella enterica Serovar Newport in China.
mSphere ( IF 4.8 ) Pub Date : 2020-05-27 , DOI: 10.1128/msphere.00163-20
Narayan Paudyal 1, 2 , Hang Pan 1 , Beibei Wu 3 , Xiao Zhou 1 , Xin Zhou 1 , Wenqing Chai 1 , Qingqing Wu 1 , Shuning Li 1 , Fang Li 1 , Guimin Gu 4 , Haoqiu Wang 5 , Qinghua Hu 6 , Xuebin Xu 7 , Yan Li 1, 8 , Min Yue 8, 9
Affiliation  

Salmonella enterica serovar Newport (S. Newport) infections are gradually on the rise in China from the last decade. For humans’ infections, S. Newport has been ranked among the top five serovars responsible for persistent infections, globally. A total of 290 S. Newport strains with their relevant clinical metadata were analyzed, and the strains were subjected to whole-genome sequence analysis. Among these, 62.4% (n = 181) were from diarrheic patients and 28.9% (n = 84) were from asymptomatic individuals (including adults and youngsters) while 8.6% (n = 25) were from cases of persistent diarrhea in infants (28%, n = 7) and toddlers (72%, n = 18). The association between the sequence types (STs) and the variations in the clinical presentation was statistically significant (P = 0.0432), with ST46 causing diarrhea or representing asymptomatic patients and ST31 or ST68 causing persistent diarrhea. Genomic analysis revealed that the highest proportion of the isolates (98.5%, n = 279), primarily from patients with or without diarrhea rather than from asymptomatic individuals, carried antimicrobial resistance determinants corresponding to the aminoglycosides and beta-lactams, highlighting the need for cautionary usage of antimicrobials in such patients. These findings also suggest that cases of nontyphoidal Salmonella infection with symptoms of acute diarrhea or persistent diarrhea caused by S. Newport should be handled with caution, due to the high chance of development of an antimicrobial resistance phenotype that might lead to therapeutic failures. Together, S. Newport ST31 and ST46, which have the highest frequency of carriage of multidrug resistance, are potentially responsible for antimicrobial-resistant diarrhea/persistent diarrhea in infants and children, while adult humans are more likely to be (asymptomatic) carriers of the S. Newport strains.
更新日期:2020-05-27
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