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The anti-ageing effects of a natural peptide discovered by artificial intelligence.
International Journal of Cosmetic Science ( IF 2.3 ) Pub Date : 2020-07-20 , DOI: 10.1111/ics.12635
K Kennedy 1 , R Cal 1 , R Casey 1 , C Lopez 1 , A Adelfio 1 , B Molloy 1 , A M Wall 1 , T A Holton 1 , N Khaldi 1
Affiliation  

As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many areas, including in offsetting the effects of cutaneous ageing. Here, using an artificial intelligence (AI) approach, we identified peptide RTE62G (pep_RTE62G), a naturally occurring, unmodified peptide with ECM stimulatory properties. The AI‐predicted anti‐ageing properties of pep_RTE62G were then validated through in vitro, ex vivo and proof of concept clinical testing.

中文翻译:

人工智能发现的一种天然肽的抗衰老作用。

随着皮肤老化,细胞外基质 (ECM) 蛋白质合成受损和降解酶的作用增加,表现为萎缩、皱纹和松弛。越来越多的证据表明外源性肽在许多领域的功能作用,包括抵消皮肤老化的影响。在这里,我们使用人工智能 (AI) 方法鉴定了肽 RTE62G (pep_RTE62G),这是一种天然存在的、未经修饰的肽,具有 ECM 刺激特性。然后通过体外、离体和概念验证临床测试验证 pep_RTE62G 的 AI 预测抗衰老特性。
更新日期:2020-07-20
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