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Fungal Pathogens: Shape-Shifting Invaders.
Trends in Microbiology ( IF 15.9 ) Pub Date : 2020-05-27 , DOI: 10.1016/j.tim.2020.05.001
Kyunghun Min 1 , Aaron M Neiman 2 , James B Konopka 1
Affiliation  

Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogenesis is to determine how fungal morphology impacts virulence strategies. For example, small budding cells use very different strategies to disseminate compared with long hyphal filaments. Furthermore, cell morphology must be monitored in the host, as many fungal pathogens change their shape to disseminate into new areas, acquire nutrients, and avoid attack by the immune system. This review describes the shape-shifting alterations in morphogenesis of human fungal pathogens and how they influence virulence strategies.



中文翻译:

真菌病原体:变形入侵者。

由于新的医疗程序增加了免疫受损患者的数量、破坏微生物组的抗菌抗生素以及为生物膜形成提供场所的留置医疗设备的使用增加,真菌感染呈上升趋势。了解发病机制的关键是确定真菌形态如何影响毒力策略。例如,与长菌丝相比,小芽细胞使用非常不同的策略进行传播。此外,必须在宿主中监测细胞形态,因为许多真菌病原体改变它们的形状以传播到新的区域、获取营养并避免免疫系统的攻击。这篇综述描述了人类真菌病原体形态发生的变形改变以及它们如何影响毒力策略。

更新日期:2020-05-27
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