Poly(vinyl alcohol) (PVA) hydrogels are widely employed in various biomedical applications due to their excellent biocompatibility, high water solubility, low protein adsorption, and chemical stability. In this work, two types of PVA-based hydrogels were synthesized by copolymerization of cationic [2-(methacryloyloxy) ethyl]trimethyl ammonium chloride (DMC) or zwitterionic sulfobetaine methacrylate (SBMA) with acrylated PVA (Acr-PVA), prepared through modification of the hydroxyl groups of PVA with glycidyl methacrylate (GMA). The antibacterial rates of Acr-PVA-g-PDMC hydrogels can reach 99.88% against Escherichia. coli and 99.99% against Staphylococcus. aureus. By comparison, the antibacterial rates of the Acr-PVA-g-PSBMA hydrogels can reach 88.40% against E. coli and 96% against S. aureus. Moreover, the Acr-PVA-g-PSBMA hydrogels possess better cell anti-adhesive properties than the Acr-PVA-g-PDMC hydrogels. The two types of hydrogels similarly possess macroporous structures, suitable swelling capacity, good mechanical properties and favorable cytocompatibility toward L929 cells. All results imply that charged group modified PVA hydrogels not only maintain the inherent properties of PVA but also possess excellent antibacterial and anti-adhesive properties. As such, the hydrogels show potential applications in biological materials fields.

聚乙烯醇（PVA）水凝胶具有出色的生物相容性，高水溶性，低蛋白质吸附性和化学稳定性，因此广泛用于各种生物医学应用中。在这项工作中，通过改性[2-（甲基丙烯酰氧基）乙基]三甲基氯化铵（DMC）或两性离子磺基甜菜碱甲基丙烯酸甲酯（SBMA）与丙烯酸化的PVA（Acr-PVA）的共聚反应，合成了两种基于PVA的水凝胶。 PVA的羟基与甲基丙烯酸缩水甘油酯（GMA）结合使用。Acr-PVA-g-PDMC水凝胶对大肠杆菌的抗菌率可达99.88％。大肠杆菌和99.99％的葡萄球菌。金黄色的。相比之下，Acr-PVA-g-PSBMA水凝胶对大肠杆菌的抗菌率可以达到88.40％和96％对金黄色葡萄球菌。此外，与Acr-PVA-g-PDMC水凝胶相比，Acr-PVA-g-PSBMA水凝胶具有更好的细胞抗粘着性能。两种类型的水凝胶类似地具有大孔结构，合适的溶胀能力，良好的机械性能和对L929细胞的良好细胞相容性。所有结果表明带电基团修饰的PVA水凝胶不仅保持PVA的固有特性，而且还具有出色的抗菌和抗粘特性。这样，水凝胶在生物材料领域显示出潜在的应用。