Visual field defects in chronic hemianopia can improve through visual restitution training, yet not all patients benefit equally from this long and exhaustive procedure. Here, we asked if resting-state functional connectivity prior to visual restitution could predict training success. In two training sessions of eight weeks each, 20 patients with chronic hemianopia performed a visual discrimination task by directing spatial selective attention towards stimuli presented in either hemifield, while suppressing eye movements. We examined two effects: a sensitivity change in the attended (trained) minus the unattended (control) hemifield (i.e., a training-specific improvement), and an overall improvement (i.e., a total change in sensitivity after both sessions). We then identified five visual resting-state networks and evaluated their functional connectivity in relation to both training effects. We found that the functional connectivity strength between the anterior Precuneus and the Occipital Pole Network was positively related to the attention modulated (i.e., training-specific) improvement. No such relationship was found for the overall improvement or for the other visual networks of interest. Our finding suggests that the anterior Precuneus plays a role in attention-modulated visual field improvements. The resting-state functional connectivity between the anterior Precuneus and the Occipital Pole Network may thus serve as an imaging-based biomarker that quantifies a patient's potential capacity to direct spatial attention. This may help to identify hemianopia patients that are most likely to benefit from visual restitution training.

慢性偏盲患者的视野缺损可以通过视觉恢复训练得到改善，但是并非所有患者都能从这一漫长而详尽的过程中同样受益。在这里，我们问视力恢复之前的静止状态功能连接是否可以预测训练成功。在每次为期八周的两次培训中，通过将空间选择性注意力吸引到任一半场中出现的刺激上，同时抑制了眼球运动，对20名慢性偏盲患者进行了视觉辨别任务。我们检查了两种影响：出席（训练）的敏感性变化减去无人照管（对照）的半场（即特定于训练的改善）的敏感性变化和总体改善（即两次疗程后敏感性的总变化）。然后，我们确定了五个视觉静止状态网络，并评估了它们与两种训练效果之间的功能连通性。我们发现，前足神经和枕极网络之间的功能连接强度与注意力调制（即特定于训练）的改善呈正相关。对于整体改进或其他感兴趣的视觉网络，没有找到这样的关系。我们的发现表明，前足前突在注意力调节视野的改善中起作用。因此，前足突和枕极网络之间的静止状态功能连接可以用作基于成像的生物标记，可量化患者潜在的引导空间注意力的能力。