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Molecular Cardioprotection and the Role of Exosomes: The Future Is Not Far Away
Journal of Cardiothoracic and Vascular Anesthesia ( IF 2.8 ) Pub Date : 2020-05-27 , DOI: 10.1053/j.jvca.2020.05.033
Johnny Wei 1 , Chris Hollabaugh 2 , Joshua Miller 2 , Paige C Geiger 3 , Brigid C Flynn 1
Affiliation  

Heart disease is the leading cause of death in men and women in the United States. During the past several decades, research into the role of specific intracellular mediators, called exosomes, has advanced the understanding of molecular cardioprotection. Exosomes and the micro-RNAs within them may be potential targets for the development of genetically engineered or biosimilar medications for patients in heart failure or with ischemic cardiac disease. This review discusses anesthetic implications of exosome production and the future micro-RNA applications for cardioprotection.

中文翻译:

分子心脏保护和外来体的作用:不久的将来

在美国,心脏病是导致男性和女性死亡的主要原因。在过去的几十年中,对称为胞外体的特定细胞内介质的作用的研究提高了对分子心脏保护作用的理解。外泌体和其中的微RNA可能是针对心力衰竭或缺血性心脏病患者开发基因工程或生物仿制药的潜在目标。这篇综述讨论了外泌体产生的麻醉意义以及未来的微RNA在心脏保护中的应用。

更新日期:2020-05-27
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