Mechanical twisting of amides is anticipated to enhance their reactivity considerably. Recent work published in Nature Chemistry by Fujita and co-workers demonstrates that reactive non-planar amide conformers can be bound inside a self-assembled coordination cage. The twisted amides are stabilized by the rigid cavity of the cage and are thus up to 14 times more reactive toward hydrolysis under basic conditions.

中文翻译：

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自组装配位笼内扭曲酰胺的水解

酰胺的机械扭曲有望大大提高其反应性。藤田及其同事在《自然化学》上发表的最新研究表明，反应性非平面酰胺构象异构体可以结合在自组装的配位笼内。扭曲的酰胺通过笼子的刚性腔得以稳定，因此在碱性条件下对水解的反应性高达14倍。