Endophytes are a diverse group of microorganisms present in plant tissues which include fungi and bacteria and have been utilized as therapeutic agents. They are known to produce different secondary and primary metabolites, which can be used in therapy of various diseases. The primary objective of this review is to provide an insight of symbiotic relationship between the endophytes and medicinal plants, specifically belonging to Asia, and also to give detailed information about the novel bioactive secondary metabolites produced from endophytes, that serve as potential therapeutic agents. We performed a Pubmed-based literature search and considered publications including research and review papers related to endophytes, the chemical constituents isolated from them and their therapeutic applications. Endophytes have a symbiotic relationship with the host medicinal plants. They provide specific advantages to plants such as nitrogen fixation. They also produce biologically active secondary metabolites such as alkaloids, flavonoids, terpenes/terpenoids, polyphenols, xanthenes, anthraquinones, cytochalasins, benzofurans, steroids, lignans, polysaccharides and plant growth hormones. Many of these compounds have therapeutic applications such as antimicrobial, antioxidant, anticancer, and anti-inflammatory. Endophytic microbes also constitute an important source for drug discovery. This review comprehends the use of endophytes as therapeutic agents.

内生菌是存在于植物组织中的多种微生物，包括真菌和细菌，并且已被用作治疗剂。已知它们会产生不同的次级和初级代谢产物，可用于治疗各种疾病。该综述的主要目的是深入了解内生菌与药用植物之间的共生关系，特别是属于亚洲的药用植物，并提供有关由内生菌产生的新型生物活性次生代谢物的详细信息，这些代谢物可用作潜在治疗剂。我们进行了基于Pubmed的文献搜索，并考虑了包括与内生菌有关的研究和评论论文，从中分离出的化学成分及其治疗应用的出版物。内生菌与宿主药用植物具有共生关系。它们为植物提供了特定的优势，例如固氮。它们还产生具有生物活性的次级代谢产物，例如生物碱，类黄酮，萜烯/萜类，多酚，黄嘌呤，蒽醌，细胞松弛素，苯并呋喃，类固醇，木脂素，多糖和植物生长激素。这些化合物中的许多具有治疗应用，例如抗微生物剂，抗氧化剂，抗癌剂和抗炎药。内生微生物也构成药物发现的重要来源。这篇综述理解了将内生菌用作治疗剂。多酚，黄嘌呤，蒽醌，细胞松弛素，苯并呋喃，类固醇，木脂素，多糖和植物生长激素。这些化合物中的许多具有治疗应用，例如抗微生物剂，抗氧化剂，抗癌剂和抗炎药。内生微生物也构成药物发现的重要来源。这篇综述理解了将内生菌用作治疗剂。多酚，黄嘌呤，蒽醌，细胞松弛素，苯并呋喃，类固醇，木脂素，多糖和植物生长激素。这些化合物中的许多具有治疗应用，例如抗微生物剂，抗氧化剂，抗癌剂和抗炎药。内生微生物也构成药物发现的重要来源。这项审查理解内生菌作为治疗剂的使用。