An efficient TFA/TBHP-promoted oxidative cyclisation of readily available isatins with 1,2,3,4-tetrahydroisoquinolines has been firstly developed. This protocol features simple operation, metal-free conditions and broad substrate scope. Under mild conditions, a wide range of tetracyclic quinazolinones were obtained in a highly efficient manner. Moreover, the potential utility of this strategy was demonstrated by one-step synthesis of a natural alkaloid Rutaecarpin.

中文翻译：

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TFA / TBHP促进的氧化环化反应，用于构建四环喹唑啉酮和芸香果碱

首先开发了一种高效的TFA / TBHP促进易获得的靛红与1,2,3,4-四氢异喹啉的氧化环化反应。该协议具有操作简单，无金属的条件和广泛的基材范围。在温和的条件下，可以高效地获得各种四环喹唑啉酮。此外，通过天然生物碱果胶的一步合成证明了该策略的潜在效用。