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Coadaptation of the chemosensory system with voluntary exercise behavior in mice
bioRxiv - Animal Behavior and Cognition Pub Date : 2020-05-26 , DOI: 10.1101/2020.05.24.113506
Quynh Anh Thi Nguyen , David Hillis , Sayako Katada , Timothy Harris , Crystal Pontrello , Theodore Garland , Sachiko Haga-Yamanaka

Ethologically relevant chemical senses and behavioral habits are likely to coadapt in response to selection. As olfaction is involved in intrinsically motivated behaviors in mice, we hypothesized that selective breeding for a voluntary behavior would enable us to identify novel roles of the chemosensory system. Voluntary wheel running (VWR) is an intrinsically motivated and naturally rewarding behavior, and even wild mice run on a wheel placed in nature. We have established 4 independent, artificially evolved mouse lines by selectively breeding individuals showing high VWR activity (High Runners; HRs), together with 4 non-selected Control lines, over 88 generations. We found that several sensory receptors in specific receptor clusters were differentially expressed between the vomeronasal organ (VNO) of HRs and Controls. Moreover, one of those clusters contains multiple single-nucleotide polymorphism loci for which the allele frequencies were significantly divergent between the HR and Control lines, i.e., loci that were affected by the selective breeding protocol. These results indicate that the VNO has become genetically differentiated between HR and Control lines during the selective breeding process, strongly suggesting the chemosensory receptors as quantitative trait loci (QTL) for voluntary exercise in mice. We propose that olfaction may play an important role in motivation for voluntary exercise in mammals.

中文翻译:

化学感觉系统与小鼠自愿运动行为的共适应

在选择方面,与道德相关的化学感觉和行为习惯可能会相互适应。由于嗅觉与小鼠的内在动机行为有关,因此我们假设自愿性行为的选择性繁殖将使我们能够识别化学感觉系统的新作用。自愿滚轮(VWR)是一种内在动机和自然有益的行为,甚至野生老鼠也可以在自然界中的滚轮上奔跑。我们通过选择性地繁殖表现出高VWR活性的个体(High Runners; HR)以及4个88代未选择的对照系,建立了4条独立的,人工进化的小鼠系。我们发现HRs的犁鼻器器官(VNO)和对照组之间特定受体簇中的几种感觉受体差异表达。此外,这些簇中的一个包含多个单核苷酸多态性基因座,其等位基因频率在HR和对照系之间显着不同,即受选择性育种方案影响的基因座。这些结果表明,VNO在选择性育种过程中已在HR和对照系之间遗传分化,强烈暗示化学感应受体是小鼠自愿运动的定量性状位点(QTL)。我们建议嗅觉可能在哺乳动物自愿运动的动机中起重要作用。这些结果表明,VNO在选择性育种过程中已在HR和对照系之间遗传分化,强烈暗示化学感应受体是小鼠自愿运动的定量性状位点(QTL)。我们建议嗅觉可能在哺乳动物自愿运动的动机中起重要作用。这些结果表明,VNO在选择性育种过程中已在HR和对照系之间遗传分化,强烈暗示化学感应受体是小鼠自愿运动的定量性状位点(QTL)。我们建议嗅觉可能在哺乳动物自愿运动的动机中起重要作用。
更新日期:2020-05-26
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