The changes of the linker of nucleoskeleton and cytoskeleton (LINC) complex have been studied in many muscular abnormality conditions; however, the effects of diabetes and physical activities on it have still remained to be defined. Therefore, the purpose of the this study was to evaluate the impacts of a six-week endurance training on the levels of SUN1 and Nesprin-1 proteins in Soleus and EDL muscles from diabetic wistar rats. A total number of 48 male Wistar rats (10 weeks, 200-250 gr) were randomly divided into healthy control (HC, N = 12), healthy trained (HT, N = 12), diabetic control (DC, N = 12), and diabetic trained (DT, N = 12) groups. Diabetes was also induced by a single intraperitoneally injection of streptozocin (45 mg/kg). The training groups ran a treadmill for five consecutive days within six weeks. The levels of the SUN1 and the Nesprin-1 proteins were further determined via ELISA method. The induction of diabetes had significantly decreased the levels of Nesprin-1 protein in the soleus and EDL muscles but it had no effects on the SUN1 in these muscles. As well, the findings revealed that six weeks of endurance training had significantly increased the levels of Nesprin-1 in DT and HT groups in the soleus as well as the EDL muscles; however, it had no impacts on the SUN1 in these muscles. The muscle fiber cross-sectional area (CSA) and myonuclei also decreased in diabetic control rats in both studied muscles. The training further augmented these parameters in both studied muscles in HT and DT groups. The present study provides new evidence that diabetes changes Nesprin-1 protein levels in skeletal muscle and endurance exercise training can modify it.

在许多肌肉异常情况下，已经研究了核骨架和细胞骨架（LINC）复合物接头的变化。然而，糖尿病和体育锻炼对其的影响尚待确定。因此，本研究的目的是评估为期六周的耐力训练对糖尿病性wistar大鼠Soleus和EDL肌肉中SUN1和Nesprin-1蛋白水平的影响。将总共​​48只雄性Wistar大鼠（10周，200-250 gr）随机分为健康对照（HC，N = 12），健康训练（HT，N = 12），糖尿病对照（DC，N = 12）。 ，以及接受糖尿病训练的（DT，N = 12）组。腹膜内注射链脲佐星（45 mg / kg）也可诱发糖尿病。训练小组在六周内连续五天跑步机。SUN1和Nesprin-1蛋白的水平通过ELISA方法进一步确定。糖尿病的诱导显着降低了比目鱼肌和EDL肌肉中Nesprin-1蛋白的水平，但对这些肌肉中的SUN1没有影响。同样，研究结果表明，进行了6周的耐力训练后，比目鱼以及EDL肌肉的DT和HT组的Nesprin-1水平显着增加。但是，它对这些肌肉中的SUN1没有影响。在两个研究过的肌肉中，糖尿病对照大鼠的肌纤维横截面积（CSA）和肌核也降低。训练进一步增加了HT和DT组研究肌肉的这些参数。