11β‐Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association of HSD11B1 SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals.

中文翻译：

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HSD11B1 基因的变异调节对糖尿病肾病和 1 型糖尿病胰岛素抵抗的易感性。

11β-羟基类固醇脱氢酶 1 在代谢紊乱的情况下与胰岛素抵抗 (IR) 有关，其编码基因 ( HSD11B1 ) 中的单核苷酸多态性 (SNP) 与 2 型糖尿病和代谢综合征有关。在 1 型糖尿病 (T1D) 中，IR 与慢性并发症的发展有关。我们在巴西 T1D 个体队列中调查了HSD11B1 SNP 与微血管并发症和 IR 的关联。