The Cover Feature shows the crystal structure of a recently developed tweezers‐shaped artificial receptor that is able to recognize caffeine based on trifurcate hydrogen bonding to the diaminocarbazolic unit and by CH−π/π−π interactions with the anthracene units. This readily available synthetic receptor shows a remarkable 26 μM affinity for caffeine as well as a higher selectivity for caffeine compared to theophylline and theobromine, as measured by ¹H NMR titrations and isothermal titration calorimetry. More information can be found in the Full Paper by O. Francesconi, S. Roelens, and co‐workers (DOI: 10.1002/cplu.202000114).

中文翻译：

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二氨基咔唑受体对咖啡因的有效识别

封面特征显示了最近开发的镊子形人工受体的晶体结构，该受体能够基于三叉酸酯氢键合到二氨基咔唑单元上以及通过CH-π/π-π与蒽单元的相互作用识别咖啡因。通过¹ H NMR滴定法和等温滴定量热法测得，与茶碱和可可碱相比，这种易于获得的合成受体对咖啡因具有26μM的亲和力，对咖啡因的选择性更高。可以在O.Francesconi，S.Roelens及其同事的论文全文中找到更多信息（DOI：10.1002 / cplu.202000114）。