3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin on different regions of the brain. In the present study, there are two groups of rats of which one is treated with 3-NP. Behavioral, stereological and immunohistochemical analyses were conducted. The results show that locomotor activity is largely affected and anxiety is induced up to a certain level, but there is no gross manifestation of deficit in memory. Microscopic observations illustrate damages in the hippocampus and other parts of the brain. Astrogliosis and glial scars were another finding of this study. In conclusion, although 3-NP can be used as a model of Huntington's disease, it exerts a disseminated effect on different regions of the brain.

3-硝基丙酸（3-NP）是一种霉菌毒素，广泛用于产生亨廷顿氏病大鼠模型。尽管有许多关于这种神经毒素作用的研究，但仍需要进一步研究以了解这种毒素对大脑不同区域的影响。在本研究中，有两组大鼠，其中一组用3-NP治疗。进行了行为学，体视学和免疫组化分析。结果表明，运动活动受到很大影响，并且焦虑被诱发到一定水平，但是没有记忆障碍的明显表现。显微镜观察显示出海马和大脑其他部位的损伤。星形胶质化和神经胶质疤痕是该研究的另一个发现。总之，尽管3-NP可以用作亨廷顿氏病的模型，