Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatment of symptoms of neuropathy and concomitant depression. We examined the effects of vortioxetine, a novel antidepressant with unique mechanism of action, on pain hypersensitivity and depression-like behavior in oxaliplatin-induced neuropathy model in mice (OIPN). Vortioxetine (1–10 mg/kg, p.o.) significantly and dose-dependently reduced mechanical allodynia in von Frey test and cold allodynia in acetone test in OIPN mice, in both repeated prophylactic and acute therapeutic treatment regimens. It also reduced depression-like behavior in the forced swimming test in OIPN mice, in both treatment paradigms. Its antiallodynic and antidepressive-like effects were comparable to those exerted by duloxetine (1–15 mg/kg, p.o.). The antiallodynic and antidepressive-like effects of repeatedly administered vortioxetine might be related to the increased content of 5-hydroxytryptamine (5-HT) and noradrenaline (NA), detected in the brainstem of treated OIPN mice. These results indicate that vortioxetine could be potentially useful in prevention and treatment of chemotherapy-induced neuropathy, for the relief of pain and concomitant depressive symptoms. It should be further tested to this regard in clinical settings.

慢性疼痛和抑郁通常同时发生，因此双效药物可能特别有用。随着癌症幸存者人数的增加，化疗引起的神经病患者的人数也在增加，并且迫切需要对神经病和伴随的抑郁症的症状进行令人满意的治疗。我们研究了沃替西汀（一种具有独特作用机制的新型抗抑郁药）对奥沙利铂诱导的小鼠神经病变模型 (OIPN) 中的疼痛超敏反应和抑郁样行为的影响。Vortioxetine (1–10 mg/kg, po) 在重复预防性和急性治疗性治疗方案中，Vortioxetine (1–10 mg/kg, po) 显着且剂量依赖性地减少了 OIPN 小鼠的 von Frey 试验中的机械性异常性疼痛和丙酮试验中的冷性异常性疼痛。在两种治疗范式中，它还减少了 OIPN 小鼠强迫游泳测试中的抑郁样行为。其抗异常性疼痛和抗抑郁样作用与度洛西汀 (1-15 mg/kg, po) 的作用相当。反复给予沃替西汀的抗异常性疼痛和抗抑郁样作用可能与治疗的 OIPN 小鼠脑干中检测到的 5-羟色胺 (5-HT) 和去甲肾上腺素 (NA) 含量增加有关。这些结果表明，沃替西汀可潜在地用于预防和治疗化疗引起的神经病变，以缓解疼痛和伴随的抑郁症状。应在临床环境中对此进行进一步测试。其抗异常性疼痛和抗抑郁样作用与度洛西汀 (1-15 mg/kg, po) 的作用相当。反复给予沃替西汀的抗异常性疼痛和抗抑郁样作用可能与治疗的 OIPN 小鼠脑干中检测到的 5-羟色胺 (5-HT) 和去甲肾上腺素 (NA) 含量增加有关。这些结果表明，沃替西汀可潜在地用于预防和治疗化疗引起的神经病变，以缓解疼痛和伴随的抑郁症状。应在临床环境中对此进行进一步测试。其抗异常性疼痛和抗抑郁样作用与度洛西汀 (1–15 mg/kg, po) 的作用相当。反复给予沃替西汀的抗异常性疼痛和抗抑郁样作用可能与治疗的 OIPN 小鼠脑干中检测到的 5-羟色胺 (5-HT) 和去甲肾上腺素 (NA) 含量增加有关。这些结果表明，沃替西汀可潜在地用于预防和治疗化疗引起的神经病变，以缓解疼痛和伴随的抑郁症状。应在临床环境中对此进行进一步测试。在治疗的 OIPN 小鼠的脑干中检测到。这些结果表明，沃替西汀可潜在地用于预防和治疗化疗引起的神经病变，以缓解疼痛和伴随的抑郁症状。应在临床环境中对此进行进一步测试。在治疗的 OIPN 小鼠的脑干中检测到。这些结果表明，沃替西汀可潜在地用于预防和治疗化疗引起的神经病变，以缓解疼痛和伴随的抑郁症状。应在临床环境中对此进行进一步测试。