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3D-printed Ti6Al4V scaffolds coated with freeze-dried platelet-rich plasma as bioactive interface for enhancing osseointegration in osteoporosis
Materials & Design ( IF 8.4 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.matdes.2020.108825
Shichong Qiao , Qianbin Sheng , Zuhao Li , Dongle Wu , Yu Zhu , Hongchang Lai , Yingxin Gu

Abstract The serious complications after arthroplasty in patients with osteoporosis is a challenge for orthopedics. Three-dimensional (3D)-printed porous titanium (pTi) alloys have the character of low stiffness, similar to cortical bone, and are seemed as promising materials in orthopedic applications, but limited by the bio-inert of titanium alloy. Thus, improving the bioactivity of the prosthesis and bone regeneration around the implant are crucial for the osseointegration. Herein, we established rabbit model of osteoporosis by bilateral ovariectomy, and the bioactive interface was constructed by coating 3D-printed pTi scaffolds with autologous platelet-rich plasma (PRP) prepared by traditional and Freeze-Dried methods. The pTi have advantages of ideal pore size, porosity and mechanical properties matching with bone tissue. In vitro, PRP-coated pTi significantly promoted bone marrow mesenchymal stem cells (BMSCs) attachment, proliferation, migration, and osteogenic differentiation. In vivo studies of the implant coatings were performed using osteoporosis models. The results indicated that this PRP-coated bioactive interface enhanced bone regeneration and osseointegration. Besides, compared with Traditional PRP, the Freeze-Dried PRP-coated pTi exhibited the superiority of promoting cell activity and osteogenic differentiation of BMSCs, and better bone formation. The novel Freeze-Dried PRP-coated pTi shows potential for the development of artificial prosthesis with bioactive interface for patients with osteoporosis.

中文翻译:

3D 打印的 Ti6Al4V 支架涂有冷冻干燥的富含血小板的血浆作为生物活性界面,用于增强骨质疏松症的骨整合

摘要 骨质疏松患者关节置换术后的严重并发症是骨科面临的挑战。三维 (3D) 打印的多孔钛 (pTi) 合金具有低刚度的特性,类似于皮质骨,在骨科应用中似乎是一种很有前途的材料,但受限于钛合金的生物惰性。因此,提高假体的生物活性和种植体周围的骨再生对于骨整合至关重要。在此,我们通过双侧卵巢切除术建立兔骨质疏松模型,并通过用传统方法和冻干方法制备的自体富血小板血浆(PRP)涂覆 3D 打印的 pTi 支架构建生物活性界面。pTi具有理想的孔径、孔隙率和与骨组织匹配的力学性能等优点。体外,PRP 包被的 pTi 显着促进骨髓间充质干细胞 (BMSCs) 附着、增殖、迁移和成骨分化。使用骨质疏松症模型对植入物涂层进行体内研究。结果表明,这种 PRP 涂层的生物活性界面增强了骨再生和骨整合。此外,与传统PRP相比,冻干PRP包被的pTi表现出促进BMSCs细胞活性和成骨分化的优势,以及更好的骨形成。新型冷冻干燥 PRP 涂层 pTi 显示出为骨质疏松症患者开发具有生物活性界面的人工假体的潜力。使用骨质疏松症模型对植入物涂层进行体内研究。结果表明,这种 PRP 涂层的生物活性界面增强了骨再生和骨整合。此外,与传统PRP相比,冻干PRP包被的pTi在促进BMSCs细胞活性和成骨分化以及更好的骨形成方面表现出优势。新型冻干 PRP 涂层 pTi 显示出为骨质疏松症患者开发具有生物活性界面的人工假体的潜力。使用骨质疏松症模型对植入物涂层进行体内研究。结果表明,这种 PRP 涂层的生物活性界面增强了骨再生和骨整合。此外,与传统PRP相比,冻干PRP包被的pTi表现出促进BMSCs细胞活性和成骨分化的优势,以及更好的骨形成。新型冷冻干燥 PRP 涂层 pTi 显示出为骨质疏松症患者开发具有生物活性界面的人工假体的潜力。冻干 PRP 包被的 pTi 表现出促进 BMSCs 细胞活性和成骨分化的优势,以及更好的骨形成。新型冷冻干燥 PRP 涂层 pTi 显示出为骨质疏松症患者开发具有生物活性界面的人工假体的潜力。冻干 PRP 包被的 pTi 表现出促进 BMSCs 细胞活性和成骨分化的优势,以及更好的骨形成。新型冷冻干燥 PRP 涂层 pTi 显示出为骨质疏松症患者开发具有生物活性界面的人工假体的潜力。
更新日期:2020-09-01
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