European Journal of Cell Biology ( IF 6.6 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.ejcb.2020.151087 Stefan Linder 1 , Pasquale Cervero 1
Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.
中文翻译:
脚架帽:过去,现在,观点。
在各种细胞类型中,体小体是基于肌动蛋白的突出粘附结构。它们具有广泛的功能,需要精巧的时空微调。因此,足囊由数百个不同的成分组成,它们履行特定的结构和调节功能。而且,很明显,足小体结构比以前认为的更复杂。因此,必须扩大富含肌动蛋白核心被包含粘附斑蛋白的环结构包围的经典模型,并且已经描述了一些其他亚结构,最值得注意的是富含肌动蛋白核心顶部的足小体盖。在这里,我们讨论了足小体帽的已知成分,它们的检测历史以及它们在足小体周转和功能中的潜在调节作用。