Plant-based ingredients are successfully replacing fishmeal in fish feeds. However, this practice increases the risk of feed contamination by mycotoxins that reduce production and heath associated with oxidative damage. The aim of this study was to determine whether feed contaminated with environmentally relevant concentrations of ochratoxin A (OTA) causes muscle oxidative damage in tambaqui (Colossoma macropomum), and to determine whether this feed impairs fatty acid profiles in fish meat. Final mean weight, weight gain, daily weight gain, feed efficiency, and specific growth rate were significantly lower in fish fed 1.6 and 2.4 mg OTA/kg compared to those fed basal diet, while feed conversion was significantly higher in these same groups compared to the basal group. Levels of reactive oxygen species and lipid peroxidation in muscle were significantly higher in fish fed 1.6 and 2.4 mg OTA/kg compared to those in the basal group. Likewise, muscle superoxide dismutase and glutathione peroxidase activities were significantly higher in fish fed 1.6 and 2.4 mg OTA/kg then in those fed basal feed. The total content of saturated fatty acids was significantly higher, and total content of polyunsaturated fatty acids was significantly lower in fish fed 2.4 mg OTA/kg compared to those fed basal feed. Taken together, the data suggest that OTA-contaminated feed induces oxidative damage and disturbs enzymatic and non-enzymatic antioxidant responses in tambaqui meat. The perturbations of fatty acid profiles in fish meat appears to mediated by oxidative damage, representing negative impact on fish health and presenting concerns for consumers of fish.

植物性成分已成功替代鱼饲料中的鱼粉。但是，这种做法增加了霉菌毒素污染饲料的风险，这会降低产量和与氧化损伤相关的健康。这项研究的目的是确定受环境相关浓度的och曲霉毒素A（OTA）污染的饲料是否会在tambaqui（Colossoma macropomum）中引起肌肉氧化损伤），并确定这种饲料是否会损害鱼肉中的脂肪酸谱。与饲喂基础饮食的鱼相比，饲喂1.6和2.4 mg OTA / kg的鱼的最终平均体重，体重增加，日增重，饲料效率和比生长速率显着降低，而与对照组相比，这些相同组的饲料转化率显着更高。基础群体。与基础组相比，饲喂1.6和2.4 mg OTA / kg的鱼的肌肉中活性氧和脂质过氧化水平显着更高。同样，饲喂1.6和2.4 mg OTA / kg的鱼的肌肉超氧化物歧化酶和谷胱甘肽过氧化物酶活性显着高于饲喂基础饲料的鱼。饲喂2的鱼中饱和脂肪酸的总含量显着较高，多不饱和脂肪酸的总含量显着较低。与饲喂基础饲料相比，OTA / kg为4 mg。两者合计，数据表明受OTA污染的饲料会在tambaqui肉中引起氧化损伤并干扰酶促和非酶促抗氧化反应。鱼肉中脂肪酸谱的扰动似乎是由氧化损伤介导的，对鱼的健康产生负面影响，并给鱼的消费者带来了担忧。