The aim of the present study was to analyze the effects of melatonin treatment on diabetic rat testes. Fifty albino rats were divided into the following groups: CG: control group; GD: placebo-induced and placebo-treated mice; GDI: insulin-induced and post-confirmation diabetes-induced rats; GDM: diabetes-induced and melatonin-treated post-confirmation mice and GDMS: diabetes-induced and melatonin-treated mice simultaneously. Melatonin was administered at a dose of 10 mg/kg in drinking water every day for 20 days at night. Diabetes was induced by streptozotocin (60 mg/kg) and confirmed after the fifth day of induction. Insulin was administered at 5 IU (international units)/day at different times of the day for 20 days. The testes were submitted to histopathological, morphometric, immunohistochemical and oxidative stress analysis. Melatonin moderately decreased glycemic levels, protected weight loss and morphometric changes in the testicles, increased antioxidant enzyme levels and stabilized plasma testosterone and androgen receptor levels and decreased inflammatory markers in the testicles. Showing its potential to mitigate diabetes effects.

本研究的目的是分析褪黑激素治疗对糖尿病大鼠睾丸的影响。五十只白化病大鼠分为以下几组：CG：对照组； CG：对照组。GD：安慰剂诱导和安慰剂治疗的小鼠；GDI：胰岛素诱发和确认后糖尿病诱发的大鼠；GDM：糖尿病诱导和褪黑素治疗的确认后小鼠和GDMS：糖尿病诱导和褪黑素治疗的小鼠同时进行。每天在饮用水中以10 mg / kg的剂量服用褪黑激素，每天晚上20天。链脲佐菌素（60 mg / kg）诱导糖尿病，诱导第五天后确认。在一天的不同时间以5 IU（国际单位）/天的剂量给予胰岛素，持续20天。将睾丸进行组织病理学，形态测定，免疫组织化学和氧化应激分析。褪黑激素适度降低了血糖水平，保护了睾丸的体重减轻和形态变化，增加了抗氧化酶的水平，并稳定了血浆睾丸激素和雄激素受体的水平，并降低了睾丸的炎性标志物。显示其减轻糖尿病影响的潜力。