An efficient procedure of continuous-flow microwave reactor, for oxidative bromination with HBr (hydrogen bromide) -DMSO (dimethyl sulphoxide) in large scale is described herein. The reaction is carried out in a metal-free manner, with the use of water as solvent under microwave irradiation conditions. The productivity of this continuous step attains 60 g/min under the optimal conditions, implying a theoretical productivity of 8.6 kg/day. The reaction mixture is screened by thermal insulation accelerometer to ensure the safe process of this reaction in these conditions. 4-Bromo-3-methylanisole is further reacted with formanilide in the presence of cuprous iodide (CuI) and potassium carbonate (K₂CO₃) to give 4-methoxy-2-methyldiphenylamine, a common intermediate in fine chemical industry such as dye and paper chemistry, in an isolated yield of 65.2%. with more than 200 g scale.

本文描述了连续流微波反应器用于大规模用HBr（溴化氢）-DMSO（二甲基亚砜）氧化溴化的有效方法。反应在微波辐射条件下以水为溶剂以无金属的方式进行。在最佳条件下，此连续步骤的生产率达到60 g / min，这意味着理论生产率为8.6 kg / day。通过绝热加速度计对反应混合物进行筛选，以确保在这些条件下该反应的安全过程。4-溴-3-甲基苯甲醚在碘化亚铜（CuI）和碳酸钾（K ₂ CO ₃）得到4-甲氧基-2-甲基二苯胺，这是精细化学工业中的常见中间体，例如染料和造纸化学，分离产率为65.2％。重量超过200克。