Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome. Over 90% of all cases of cancer show high expression of telomerase while in normal cells, its expression is extremely low or undetectable. Detection of telomerase activity in a wide range of breast cancer makes telomerase an interesting target for diagnosis and therapy. In this review, we have aimed to describe telomerase as a therapeutic and accurate diagnostic target in breast cancer. Telomerase performs many extracurricular activities apart from maintaining telomere length; here, we have also tried to address its role in epithelial-mesenchymal transition (EMT) of breast cancer progression.

中文翻译：

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端粒酶作为乳腺癌药物靶点的评估

端粒酶是一种特殊的酶，可维持染色体末端的端粒长度。超过 90% 的癌症病例显示端粒酶高表达，而在正常细胞中，其表达极低或检测不到。在广泛的乳腺癌中检测端粒酶活性使端粒酶成为诊断和治疗的有趣目标。在这篇综述中，我们旨在将端粒酶描述为乳腺癌的治疗和准确诊断靶点。除了保持端粒长度外，端粒酶还执行许多课外活动；在这里，我们还试图解决其在乳腺癌进展的上皮间充质转化 (EMT) 中的作用。