Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET.,Journal of Assisted Reproduction and Genetics

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Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET.
Journal of Assisted Reproduction and Genetics ( IF 3.1 ) Pub Date : 2020-05-25 , DOI: 10.1007/s10815-020-01793-8
Sai-Jiao Li _{1,

2} , Yan-Xiang Cheng ₃ , Ye-Shang _{1,

2} , Dan-Ni Zhou _{1,

2} , Yin Zhang _{1,

2} , Tai-Lang Yin _{1,

2} , Jing Yang _{1,

2}

Affiliation

Purpose

This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh^+/−, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.

Methods

A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh^+/−, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group.

Results

Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively, P < 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%, P < 0.05) or ICSI (50.0% vs. 2.0%, P < 0.05) insemination, female carriers (23.08% vs. 2.87%, P < 0.05) or male carriers (44.44% vs. 2.87%, P < 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%, P < 0.05) and clinical pregnancy rate (78.6% vs. 40.65%, P < 0.05). 1/9/16qh^+/− had no apparent adverse effect on the patient’s clinical outcomes.

Conclusions

Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types.

中文翻译：

体外受精-胚胎移植后的染色体多态性与生殖结局有关。

目的

这项研究旨在调查详细的染色体多态性类型（1/9 / 16qh ^+/-，D / G组多态性和inv（9））对IVF-ET结果的影响。

方法

共有1335名进行IVF / ICSI的不育夫妇入组并全面分析了三种详细类型的染色体多态性（1/9 / 16qh ^+/-，D / G组多态性和inv（9））之间的相关性IVF / ICSI胚胎移植。比较了染色体多态性组和对照组的受精率，卵裂率，优质胚胎率，临床妊娠率，着床率和早期流产率。

结果

与女性不育症相关的inv（9）和D / G组染色体多态性均显着降低了进行IVF人工授精的2PN裂解率（分别为86.44％对97.58％和90.67％对97.58％，P <0.05）， inv（9）不利于提高早期流产率，接受IVF（21.4％vs. 3.0％，P <0.05）或ICSI（50.0％vs. 2.0％，P <0.05）人工授精，女性携带者（23.08％vs. 2.87％，P <0.05）或男性携带者（44.44％vs. 2.87％，P <0.05）。对于D / G组，ICSI人工授精可提高植入率（44.8％vs. 23.69％，P <0.05）和临床妊娠率（78.6％vs. 40.65％，P <0.05）。1/9 / 16qh ^+/- 对患者的临床结局无明显不良影响。