The objective of this study was to investigate of selenium (Se), zinc (Zn), chromium (Cr), and vanadium (V) levels in blood serum, hair, and urine of adult obese patients. A total of 199 lean and 196 obese subjects were enrolled in the study. Serum, hair, and urinary metal and metalloid analysis were performed by inductively coupled plasma mass spectrometry at NexION 300D (PerkinElmer Inc., USA). The results established that obese subjects were characterized by 47% and 30% lower serum Cr and V levels compared with controls, respectively, whereas serum Se levels exceeded control values by 9%. In contrast, hair Cr, Se, and V content in obese subjects exceeded the control values by 51%, 21%, and 50%, respectively. In turn, hair Zn levels were found to be significantly lower by 11% compared with the lean control values. In urine, the levels of V and Zn were found to be 30% and 18% higher in obese patients. Prevalence of hypertension in obese subjects was associated with a trend for impaired Se and Zn levels. In a regression model adjusted for age, gender, hypertension, atherosclerosis, and glucose intolerance, serum Cr, V, and hair Zn were inversely associated with body mass index (BMI), whereas hair Se was considered as the positive predictor. Our data allow proposing that the observed alterations may at least partially contribute to metabolic disturbances in obesity. In turn, monitoring of Se exposure in a well-nourished adult population is required to reduce its potential contribution to obesity.

中文翻译：

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通过电感耦合等离子体质谱法评估肥胖成人的血清、头发和尿液样本中的硒、锌、铬和钒水平。

本研究的目的是调查成年肥胖患者血清、头发和尿液中硒 (Se)、锌 (Zn)、铬 (Cr) 和钒 (V) 的含量。共有 199 名瘦人和 196 名肥胖受试者参加了这项研究。在 NexION 300D (PerkinElmer Inc., USA) 上通过电感耦合等离子体质谱法对血清、头发和尿液中的金属和类金属进行分析。结果表明，与对照组相比，肥胖受试者的血清 Cr 和 V 水平分别降低 47% 和 30%，而血清硒水平超过对照值 9%。相比之下，肥胖受试者的头发 Cr、Se 和 V 含量分别超过对照值 51%、21% 和 50%。反过来，与瘦肉对照值相比，头发锌含量显着降低了 11%。在尿液中，发现肥胖患者的 V 和 Zn 水平高出 30% 和 18%。肥胖受试者的高血压患病率与硒和锌水平受损的趋势有关。在调整了年龄、性别、高血压、动脉粥样硬化和葡萄糖耐受不良的回归模型中，血清 Cr、V 和头发锌与体重指数 (BMI) 呈负相关，而头发硒被认为是阳性预测因子。我们的数据允许提出观察到的改变可能至少部分导致肥胖的代谢紊乱。反过来，需要在营养良好的成年人群中监测硒暴露，以减少其对肥胖的潜在影响。在调整了年龄、性别、高血压、动脉粥样硬化和葡萄糖耐受不良的回归模型中，血清 Cr、V 和头发锌与体重指数 (BMI) 呈负相关，而头发硒被认为是阳性预测因子。我们的数据允许提出观察到的改变可能至少部分导致肥胖的代谢紊乱。反过来，需要在营养良好的成年人群中监测硒暴露，以减少其对肥胖的潜在影响。在调整了年龄、性别、高血压、动脉粥样硬化和葡萄糖耐受不良的回归模型中，血清 Cr、V 和头发锌与体重指数 (BMI) 呈负相关，而头发硒被认为是阳性预测因子。我们的数据允许提出观察到的改变可能至少部分导致肥胖的代谢紊乱。反过来，需要在营养良好的成年人群中监测硒暴露，以减少其对肥胖的潜在影响。