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Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects.
International Ophthalmology ( IF 1.6 ) Pub Date : 2020-05-23 , DOI: 10.1007/s10792-020-01408-2
Xiaojie Wang 1 , Juanjuan Chen 2 , Shaodan Zhang 1 , Xiao Shang 1 , Kun Zhou 1 , Yuan Lan 1 , Jianqiu Cai 2 , Yuanbo Liang 1
Affiliation  

Purpose

To investigate the diurnal fluctuations of macular vessel density (VD) in primary open-angle glaucoma (POAG) and healthy subjects using optical coherence tomography angiography.

Methods

A total of 22 POAG eyes and 15 healthy eyes were included in this study. Macular VD, intraocular pressure, and blood pressure were repeatedly measured from 8 AM to 8 PM at a 2-h interval on a single day. Main outcome measures: the macular VD measurements, their diurnal fluctuations, including the difference between their maximal and minimal value (max–min) and their coefficient of variation (CV) in superficial capillary plexus (SCP) and deep capillary plexus (DCP). The mixed-effects model was performed to compare the fluctuations between groups.

Results

After adjusted age, the diurnal fluctuations of macular VD in SCP and DCP were significantly higher in POAG eyes compared with healthy subjects (max–min: 6.65 ± 3.54%, 3.92 ± 3.63%, respectively; p = 0.037 and CV: 0.06 ± 0.03, 0.04 ± 0.03, respectively; p = 0.003). The fovea VD in DCP of POAG eyes was higher than in healthy subjects (31.52 ± 4.68% and 25.71 ± 3.70%, p = 0.009). However, there was no significant difference between the fovea VD in SCP in two groups (20.97 ± 4.75% and 19.29 ± 4.35%, p = 0.670). The diurnal macular superficial VD measured in most of the participants was lower in the morning.

Conclusions

Whether it is a max–min or a CV assessment method, the POAG eyes had more significant diurnal fluctuations of macular VD than healthy controls, suggesting impaired vascular autoregulation in POAG eyes.



中文翻译:

原发性开角型青光眼和健康受试者黄斑血管密度的昼夜波动。

目的

使用光学相干断层扫描血管成像技术调查原发性开角型青光眼(POAG)和健康受试者的黄斑血管密度(VD)的昼夜波动。

方法

这项研究总共包括22只POAG眼睛和15只健康眼睛。在一天中的2小时间隔内,从上午8点至晚上8点重复测量黄斑VD,眼内压和血压。主要预后指标:黄斑区VD测量,昼夜波动,包括​​其最大和最小值(max-min)之间的差异以及其在浅表毛细血管丛(SCP)和深毛细血管丛(DCP)中的变异系数(CV)。进行混合效果模型以比较组之间的波动。

结果

调整年龄后,与健康受试者相比,POAG眼中SCP和DCP的黄斑VD的昼夜波动明显高于健康受试者(最大值-最小值:6.65±3.54%,3.92±3.63%;p  = 0.037和CV:0.06±0.03 ,分别为0.04±0.03;p  = 0.003)。POAG眼DCP的中央凹VD高于健康受试者(31.52±4.68%和25.71±3.70%,p  = 0.009)。但是,两组的SCP中央凹VD之间没有显着差异(20.97±4.75%和19.29±4.35%,p  = 0.670)。在大多数参与者中测得的昼夜性黄斑浅表VD在早晨较低。

结论

无论是最大-最小值还是CV评估方法,POAG眼的黄斑VD的昼夜波动都比健康对照组大,这表明POAG眼的血管自动调节功能受损。

更新日期:2020-05-23
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