Interleukin-33 (IL-33) is produced by various types of cells under physical or pathological conditions. As a multifunctional partner in health and disease, current evidence reveals that IL-33 also participates in several metabolic processes. IL-33 has been proven to contribute to regulating the activity of ST2⁺ group 2 innate lymphoid cells and regulatory T cells in adipose, which leads to the shift of insulin sensitivity and glucose clearance in glucose metabolism, thermogenesis, and adipocyte beiging in adipose metabolism. In this review, we briefly summarize the biological characteristics of Il-33 and discuss its regulatory function in glucose and adipose metabolism. By clarifying the underlying mechanism of IL-33, we highlight the crosstalk between immune response and metabolic processes mediated by IL-33.

中文翻译：

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IL-33在代谢调节中的基本功能。

白细胞介素33（IL-33）由各种类型的细胞在物理或病理条件下产生。作为健康和疾病方面的多功能伙伴，目前的证据表明IL-33也参与了一些代谢过程。已证明IL-33有助于调节脂肪中ST2 ⁺ 2组先天性淋巴样细胞和调节性T细胞的活性，从而导致胰岛素代谢和葡萄糖清除，葡萄糖代谢，产热和脂肪代谢中脂肪的转变。 。在这篇综述中，我们简要概述了Il-33的生物学特性，并讨论了其在葡萄糖和脂肪代谢中的调节功能。通过阐明IL-33的潜在机制，我们强调了免疫应答与IL-33介导的代谢过程之间的串扰。