Abstract

There has been much interest in the clinical trial of GV972 for treatment of Alzheimer’s disease in that the data have indicated that the compound is protective against cognitive decline. This effect has been attributed to a remodelling of the gut microbiota. I suggest that the effect might be caused by an antiviral action of GV971 against herpes simplex virus type 1 in brain, which many studies have strongly implicated as having a major role in Alzheimer’s disease. The antiviral action of GV971 is proposed on the basis that it is an acidic polysaccharide consisting of linear sodium oligomannurarate molecules of a range of sizes, derived from brown algae. Marine-derived polysaccharides are well known for possessing various bioactivities, including antiviral and antibacterial properties.

中文翻译：

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假设：Green Valley的GV971药物对认知功能下降的表观保护作用是否源自对脑中1型单纯疱疹病毒的抗病毒作用？

摘要

GV972用于治疗阿尔茨海默氏病的临床试验引起了人们的极大兴趣，因为数据表明该化合物可预防认知功能减退。这种作用归因于肠道菌群的重塑。我建议，这种作用可能是由于GV971对1型单纯疱疹病毒在脑中的抗病毒作用引起的，许多研究强烈暗示该作用在阿尔茨海默氏病中起主要作用。提出GV971的抗病毒作用是因为它是一种酸性多糖，由棕色藻类衍生而来，由线性大小不等的甘露糖酸钠分子组成。众所周知，海洋来源的多糖具有多种生物活性，包括抗病毒和抗菌特性。