Background:Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke. Objectives:To evaluate the predictive value of estimated whole blood viscosity(WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI). Materials & methods:Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Serial echocardiographic examinations were performed within 24h of admission, before hospital discharge, and at 1, 3, 6 and 12 months following hospital discharge. WBV was calculated according to de Simones formula. Results:One hundred patients (12.8%) developed thrombus formation within one year following AAMI. Patients with left ventricular thrombus (LVT) had significantly higher WBV values. Supramedian values of WBV at both low (0.5 sec−1) and high (208 sec−1) shear rates were found to be an independent predictor of LVT development. Conclusion:As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction.

中文翻译：

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由de Simeone公式估算的全血粘度对预测急性前壁心肌梗塞后一年内左心室血栓形成的有用性。

背景：尽管ST段心肌梗死（STEMI）的治疗有所改善，但左心室血栓形成仍是令人担忧的并发症，可能导致全身性血栓栓塞和中风。目的：评估估计的全血粘度（WBV）对幸存的急性前壁心肌梗死（AAMI）患者的左室血栓形成的预测价值。材料与方法：连续纳入经皮治疗的780例AAMI患者。在入院后24小时内，出院前以及出院后的1、3、6和12个月进行连续超声心动图检查。WBV根据de Simones公式计算。结果：AAMI后一年内有100名患者（12.8％）出现了血栓形成。左室血栓（LVT）患者的WBV值明显较高。在低（0.5 sec-1）和高（208 sec-1）剪切速率下，WBV的中上值是LVT发展的独立预测因子。结论：WBV作为一种易于获取的参数，可能是急性前壁心肌梗死后一年内LVT形成的有用预测指标。