Abstract The Latinx population in the United States is disproportionately affected by HIV. Our community-based participatory research partnership developed, implemented and evaluated a Spanish-language peer navigation intervention designed to increase HIV testing and condom use among social networks of immigrant Spanish-speaking Latinx gay, bisexual and other men who have sex with men (GBMSM) and transgender women (TW). We randomized 21 social networks of Latinx GBMSM and TW, ages 18–55 years, to the intervention, known as HOLA, or a waitlist control group. Social network participants (n = 166) completed structured assessments at baseline and 12-month follow-up (24 months after baseline). Follow-up retention was 95%. Individual in-depth interviews with a sample of participants documented their intervention-related experiences, needs, and priorities to inform future research. At follow-up, HOLA participants reported increased HIV testing (adjusted odds ratio = 8.3; 95% CI = 3.0–23.0; P < 0.0001). All study participants reported increased condom use; there was no significant difference between HOLA and waitlist control participants. In-depth interviews identified critical intervention elements and impacts and community needs and priorities. The HOLA intervention is effective for increasing HIV testing among Latinx GBMSM and TW, an initial step within the HIV prevention and care continua, and may be adaptable to promote pre-exposure prophylaxis uptake.

中文翻译：

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在美国，混合移民身份的拉丁同志GBMSM和跨性别妇女中预防艾滋病毒的同伴航行干预措施：结果，观点和对PrEP摄取的影响。

摘要在美国，拉丁裔人口受艾滋病的影响尤其严重。我们基于社区的参与性研究合作伙伴关系开发，实施和评估了西班牙语同行导航干预措施，旨在增加在西班牙语为西班牙语的移民，拉丁裔同性恋，双性恋和其他与男性发生性关系的男性的社交网络中进行艾滋病毒检测和使用避孕套（GBMSM）和变性女性（TW）。我们将年龄在18-55岁之间的21个Latinx GBMSM和TW社交网络随机分配给干预措施，即HOLA或候补对照组。社交网络参与者（n = 166）在基线和12个月的随访（基线后24个月）完成了结构化评估。随访保留率为95％。通过对参与者的样本进行的深入访谈记录了他们与干预相关的经验，需求，和优先事项，以告知未来的研究。随访时，HOLA参与者报告了艾滋病毒检测增加（调整后的优势比= 8.3； 95％CI = 3.0–23.0； P <0.0001）。所有研究参与者均报告安全套使用增加；HOLA和等待清单控制参与者之间没有显着差异。深入访谈确定了关键的干预要素和影响以及社区的需求和优先事项。HOLA干预措施可以有效地提高Latinx GBMSM和TW之间的HIV检测水平，这是HIV预防和护理连续性体系中的第一步，并且可能适于促进暴露前预防措施的摄入。HOLA和等待清单控制参与者之间没有显着差异。深入访谈确定了关键的干预要素和影响以及社区的需求和优先事项。HOLA干预措施可以有效地提高Latinx GBMSM和TW之间的HIV检测水平，这是HIV预防和护理连续性体系中的第一步，并且可能适于促进暴露前预防措施的摄入。HOLA和等待清单控制参与者之间没有显着差异。深入访谈确定了关键的干预要素，影响以及社区需求和优先事项。HOLA干预措施可以有效地提高Latinx GBMSM和TW之间的HIV检测水平，这是HIV预防和护理连续性体系中的第一步，并且可能适于促进暴露前预防措施的摄入。