Purpose

To investigate the relationship between αB-crystallin levels in the vitreous of patients with rhegmatogenous retinal detachment (RRD) and correlate these levels with the presence of proliferative vitreoretinopathy (PVR) and to the extent of RRD.

Methods

Prospective, cross-sectional study. Vitreous samples were collected from twenty-six patients with RRD at the surgical repair. PVR was evaluated using the Updated Proliferative Vitreoretinopathy Grade Classification system. RRD area was measured using ultra-widefield retinal photographs. The concentration of αB-crystallin in the vitreous was measured using an enzyme-linked immunosorbent assay kit.

Results

The average concentration of αB-crystallin was significantly higher in the PVR Grade B and C group (97.83 ± 69.47) than in the PVR (-) and Grade A group (39.43 ± 13.53 ng/mL, P = 0.005). The level of αB-crystallin was also significantly higher in patients with large RD area (RD area > 1/4, 85.52 ± 66.07 ng/mL) than in patients with small RD area (RD area ≤ 1/4, 39.20 ± 13.02 ng/mL, P = 0.016).

Conclusions

The level of αB-crystallin was significantly increased in the vitreous of RRD patients with high-grade PVR and large RD area. This finding suggests that αB-crystallin may function as an endogenous mediator in fibrotic processes in RRD patients.

中文翻译：

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血源性视网膜脱离患者玻璃体αB-晶状体蛋白升高，并与增生性玻璃体视网膜病变和视网膜脱离区域相关。

目的

目的：探讨血源性视网膜脱离（RRD）患者玻璃体中αB-晶状体蛋白水平之间的关系，并将这些水平与增生性玻璃体视网膜病变（PVR）的存在以及RRD的程度相关联。

方法

前瞻性，横断面研究。在手术修复时从26例RRD患者中收集玻璃体样品。使用更新的增殖性玻璃体视网膜病变等级分类系统对PVR进行评估。使用超宽视场视网膜照片测量RRD面积。使用酶联免疫吸附测定试剂盒测量玻璃体内αB-晶状体蛋白的浓度。

结果

PVR B级和C级组的αB-晶状蛋白的平均浓度（97.83±69.47）显着高于PVR（-）和A级组（39.43±13.53 ng / mL，P  = 0.005）。RD面积大（RD面积> 1/4，85.52±66.07 ng / mL）的患者的αB-晶状蛋白水平也显着高于RD面积小（RD面积≤1/4，39.20±13.02 ng的患者） /毫升，P  = 0.016）。

结论

高级别PVR和大RD区域的RRD患者的玻璃体中αB-晶状蛋白的水平显着增加。这一发现表明，αB-晶状体蛋白可能在RRD患者的纤维化过程中起内源性介质的作用。