Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation.

中文翻译：

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诊所中的水凝胶。

可注射水凝胶是药物输送和组织工程应用中研究最广泛，用途最广泛的技术之一。水凝胶的多功能性来自于其可调节的结构，这是由于材料工程，聚合物科学和化学等领域的巨大进步而实现的。这些领域的进步继续导致新聚合物的发明，交联聚合物的新方法，制造水凝胶的新策略以及水凝胶在改善医疗保健方面的新应用。从癌症治疗到美学矫正到脊柱融合，各种水凝胶技术已获得医疗保健方面的监管批准。除了这些应用之外，还在临床环境中研究水凝胶用于组织再生，失禁和其他应用。这里，我们分析了可注射水凝胶技术的当前临床前景，包括已被临床批准或正在临床环境中研究的水凝胶。我们总结我们的分析以突出水凝胶已获得持续成功的关键临床领域，并进一步讨论可能限制其未来临床翻译的挑战。