In this study, methacrylation of alginate was carried out by reacting sodium alginate with methacrylic anhydride in the presence of sodium hydroxide. Separately synthesized nano-hydroxyapatite (nano-HAp) powder was surface functionalized using mercaptopropionic acid and ethylene glycol methacrylate phosphate (EGMP) in the presence of azobisisobutyronitrile benzene as a free radical initiator in a nitrogen atmosphere. Methacrylated alginate solution was mixed with the required amount of surface-functionalized HAp nanoparticles in the presence of 0.05% Irgacure 2959 as a photoinitiator and was placed at the centre of a 8 kW UV light source (265 nm) to prepare photo-crosslinked bone paste. X-ray diffraction analysis indicated that surface functionalization did not alter phase purity of HAp nanopowder in the prepared paste. The graft polymerization of EGMP on the surface of HAp was confirmed by the presence of the 1732 cm −1 band, which belongs to C=-O stretching of EGMP, ...

中文翻译：

---

用于骨组织工程的光交联海藻酸盐纳米羟基磷灰石糊。

在这项研究中，海藻酸钠的甲基丙烯酸化是通过海藻酸钠与甲基丙烯酸酐在氢氧化钠存在下的反应进行的。在氮气氛中，在偶氮二异丁腈苯作为自由基引发剂的存在下，使用巯基丙酸和乙二醇甲基丙烯酸酯（EGMP）对单独合成的纳米羟基磷灰石（nano-HAp）粉末进行表面功能化。在作为光引发剂的 0.05% Irgacure 2959 存在下，将甲基丙烯酸化海藻酸盐溶液与所需量的表面功能化 HAp 纳米粒子混合，并放置在 8 kW 紫外光源（265 nm）的中心以制备光交联骨膏. X 射线衍射分析表明，表面功能化不会改变制备的糊剂中 HAp 纳米粉末的相纯度。