Abstract

Ten thiophene derivatives (1–10), including two previously undescribed ones (1 and 2), have been obtained and structurally characterized from the aerial parts of a traditional Chinese herb Eclipta prostrata. Six of them with one chiral center were identified to be scalemic mixtures, and the pure enantiomers of two isolates (1 and 3) were successfully separated via chemical derivatization and chiral HPLC, with the absolute configurations being established by analysis of optical rotations. All the thiophenes were subjected to a series of assays and compounds 9 and 10 exhibited mild antibacterial activity against Staphylococcus aureus.

中文翻译：

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旱莲草地上部分的噻吩对映体

摘要

十种噻吩衍生物 (1-10)，包括两种先前未描述的衍生物 (1 和 2)，已从传统中草药旱莲草的地上部分获得并进行结构表征。其中具有一个手性中心的六个被鉴定为比例混合物，并且通过化学衍生化和手性 HPLC 成功分离了两个分离物（1 和 3）的纯对映异构体，通过旋光度分析确定了绝对构型。所有噻吩都进行了一系列检测，化合物 9 和 10 对金黄色葡萄球菌表现出温和的抗菌活性。