Depression is a major contributor to the overall global burden of disease, with high prevalence and relapse rate. Several factors have been considered in order to reduce the depression burden. Among them, physical activity (PA) showed a potential protective role. However, evidence is contrasting probably because of the differences in PA measurement. The aim of this systematic review with meta-analysis is to assess the association between objectively measured PA and incident and prevalent depression. The systematic review was conducted according to methods recommended by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant papers published through 31 August 2019 were identified searching through the electronic databases PubMed/MEDLINE, Excerpta Medica dataBASE (Embase), PsycINFO, Scopus, Web of Science (WoS), and the Cochrane Library. All analyses were conducted using ProMeta3. Finally, 42 studies met inclusion criteria. The overall Effect size (ES) of depression for the highest vs. the lowest level of PA was −1.16 [(95% CI = −1.41; −0.91), p-value < 0.001] based on 37,408 participants. The results of the meta-analysis showed a potential protective effect of PA on prevalent and incident depression.

中文翻译：

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抑郁症和客观测量的体育活动：系统评价和荟萃分析。

抑郁症是全球总体疾病负担的主要因素，其患病率和复发率很高。为了减轻抑郁负担，已经考虑了几个因素。其中，体育锻炼（PA）显示出潜在的保护作用。但是，证据的对比可能是由于PA测量的差异。这项荟萃分析的系统评价的目的是评估客观测量的PA与事件和普遍抑郁之间的关联。根据Cochrane协作组织推荐的方法和系统评价和荟萃分析的首选报告项目（PRISMA）指南，进行了系统评价。通过电子数据库PubMed / MEDLINE，Excerpta Medica数据库（Embase），PsycINFO，Scopus，Web of Science（WoS）和Cochrane库。所有分析均使用ProMeta3进行。最后，有42项研究符合纳入标准。最高水平与最低水平的PA引起的抑郁症的总体影响大小（ES）为-1.16 [（95％CI = -1.41; -0.91），p值<0.001]，基于37,408名参与者。荟萃分析的结果表明，PA对流行和突发性抑郁症具有潜在的保护作用。