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Evaluation of DNA methylation status of toll-like receptors 2 and 4 promoters in Behcet's disease.
The Journal of Gene Medicine ( IF 3.5 ) Pub Date : 2020-05-25 , DOI: 10.1002/jgm.3234
Sousan Kolahi 1 , Nadereh Rashtchizadeh 1 , Aida Malek Mahdavi 1 , Jafar Farhadi 1 , Alireza Khabbazi 1 , Ebrahim Sakhinia 1, 2 , Neda Bahavarnia 1 , Mohammad Jahed Farajzadeh Polsangi 1 , Zohreh Babaloo 1 , Mehrdad A Estiar 3, 4
Affiliation  

Altered innate immune function plays an important role in the initiation of inflammatory response in Behcet's disease (BD). Toll‐like receptors (TLRs) are the master regulators of the innate immune system. Because the role of TLRs remains unknown in the pathogenesis of BD, the present study aimed to evaluate the expression levels and methylation status of the TLR2 and TLR4 promoters in patients with BD.

中文翻译:

评估 Behcet 病中 toll 样受体 2 和 4 启动子的 DNA 甲基化状态。

先天免疫功能的改变在白塞病 (BD) 炎症反应的启动中起着重要作用。Toll 样受体 (TLR) 是先天免疫系统的主要调节剂。由于 TLR 在 BD 发病机制中的作用尚不清楚,本研究旨在评估 BD 患者中 TLR2 和 TLR4 启动子的表达水平和甲基化状态。
更新日期:2020-05-25
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