We read with interest the paper “Preoperative evaluation of microvascular invasion with circulating tumor DNA in operable hepatocellular carcinoma” published in an upcoming issue of Liver International.¹ It is an elegant study that looked at the association between microvascular invasion (MVI) and circular tumor DNA (ctDNA) for patients with surgical hepatocellular carcinoma (HCC) and their outcome prediction. Although the findings highlight the role of ctDNA in predicting the existence of MVI in HCC, there are some methodological flaws which may deserve the authors' attention.

中文翻译：

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用ctDNA预测HCC中的微血管侵袭：陷阱是什么？

我们感兴趣地阅读了即将出版的《肝病国际》上发表的论文“术前评估可循环性肝细胞癌中循环肿瘤DNA对微血管侵袭的作用”。¹这是一项出色的研究，研究了手术性肝细胞癌（HCC）患者的微血管浸润（MVI）与圆形肿瘤DNA（ctDNA）之间的关联及其预后。尽管这些发现突出了ctDNA在预测肝癌中MVI的存在中的作用，但仍有一些方法学上的缺陷值得作者注意。