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Physicochemical evaluation of new tetrahydroacridine and iodobenzoic acid hybrids as the next step in the design of potential drugs for treating Alzheimer's disease.
Biomedical Chromatography ( IF 1.8 ) Pub Date : 2020-05-25 , DOI: 10.1002/bmc.4906
Paweł Kręcisz 1 , Kamila Czarnecka 1 , Paweł Szymański 1
Affiliation  

Tacrine derivatives containing iodobenzoic acid were developed as a novel multitarget‐directed ligand and find potential application in the treatment of Alzheimer's disease. The aim of this study is to perform a physicochemical profile of this series. Experimental log P and pKa values were determined and compared with those already calculated. The results indicated better values of the tested compounds than the values predicted using computer software. The stability report was obtained using the developed HPLC method. The stability assay in different environment conditions provided information about the photosensitivity of these compounds and a proper method for the storage of this series of compounds.

中文翻译:

对新的四氢and啶和碘代苯甲酸杂化物的物理化学评估,是设计治疗阿尔茨海默氏病的潜在药物中的下一步。

含碘苯甲酸的他克林衍生物被开发为一种新型的多靶标定向配体,并在治疗阿尔茨海默氏病中具有潜在的应用前景。这项研究的目的是执行该系列的理化特征。确定实验log  P和p K a值,并将其与已经计算出值进行比较。结果表明测试化合物的值比使用计算机软件预测的值更好。使用开发的HPLC方法获得稳定性报告。在不同环境条件下的稳定性测定提供了有关这些化合物的光敏性的信息以及用于存储该系列化合物的适当方法。
更新日期:2020-05-25
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